Methods of stimulating cartilage formation

Procedes de stimulation de la formation de cartilage

Abstract

The disruption of the murine ROR2 gene leads to profound skeletal abnormalities, with essentially all endochondrally derived bones foreshortened and/or misshapen, albeit to differing degrees. ROR2 is selectively expressed in the chondrocytes of all developing cartilage anlagen, where it plays a critical role during initial growth and patterning, as well as subsequently in the proliferating chondrocytes of mature growth plates, where it is required for normal expansion. As ROR2 appears to play a critical role in cartilage formation and it may be useful in developing therapeutic strategies to treat diseases of cartilage such as osteoarthritis.
La rupture du gène murin ROR2 conduit à de profondes anomalies du squelette, telles que des raccourcissements et/ou des déformations observés dans presque tous les os d'origine endochondrale, bien qu'à des degrés différents. ROR2 est exprimé sélectivement dans les chondrocytes de tout primordium de cartilage, où il joue un rôle critique au cours de la croissance initiale et de la structuration fonctionnelle, ainsi qu'ultérieurement dans les chondrocytes proliférants de cartilages de conjugaison à maturité, où il est nécessaire à un développement normal. ROR2 semble jouer un rôle critique dans la formation du cartilage et il peut s'avérer utile au développement de stratégies thérapeutiques destinées au traitement de maladies du cartilage telles que l'arthrose.

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