Cristaux et structures kdops ou cks de synthetase cmp-kdo

CRYSTALS AND STRUCTURES OF CMP-KDO SYNTHETASE KdoPS or CKS

Abstract

The present invention provides machine readable media embedded with the threedimensional molecular structure coordinates of CMP-KDO synthetase, and subsets thereof, including binding pockets, methods of using the structure to identify and design affecters, including inhibitors and activator, mutants of KdoPS or CKS, and compounds and compositions that affect KdoPS or CKS activity.
L'invention concerne des supports lisibles par machine dans lesquels sont intégrés les coordonnées de la structure moléculaire tridimensionnelle de la synthétase CMP-KDO, et de sous-ensembles de celle-ci, notamment des poches de liaison. L'invention concerne également des procédés d'utilisation de la structure en vue d'identifier et de mettre au point leur modificateur, notamment des inhibiteurs et des activateurs sur les mutants de KdoPS ou CKS, et sur des composés et des compositions modifiant l'activité des KdoPS ou CKS.

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