Therapeutic applications of p53 isoforms in regenerative medicine, aging and cancer

Applications thérapeutiques des isoformes p53 en médecine régénératrice, pour lutter contre le vieillissement et le cancer


The present invention provides methods and compositions for modulating cell senescence and cell proliferation using isoforms of the p53 tumor suppressor protein. The methods and compositions of the invention find use in inhibiting cancer cell growth or in generating populations of cells for tissue regeneration through the modulation of cell senescence and proliferation.
La présente invention concerne des procédés et des compositions pour moduler la sénescence cellulaire et la prolifération cellulaire avec des isoformes de la protéine suppresseur de tumeur p53. Les procédés et les compositions de l'invention sont utiles pour inhiber la croissance cellulaire cancéreuse ou pour générer des populations de cellules à des fins de régénération tissulaire par modulation de la sénescence et de la prolifération cellulaires.




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Patent Citations (1)

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    WO-2009029054-A1March 05, 2009Agency For Science, Technology And ResearchP53 isoform gene(s) and uses thereof

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    US-8377637-B2February 19, 2013The Ohio State University Research Foundation, Department Of Health And Human ServicesMicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer using miR-17-3P
    US-9125923-B2September 08, 2015The Ohio State University, Fudan University, The United States Of America As Represented By The Secretary Of The Dept. Of Health And Human ServicesUse of MiR-26 family as a predictive marker for hepatocellular carcinoma and responsiveness to therapy